Mechanisms of Insulin Resistance A Central Role of RLIP76 in Regulation of Glycemic Control Running Title: Mechanisms of Insulin Resistance
نویسندگان
چکیده
Running Title: Mechanisms of Insulin Resistance Sanjay Awasthi*, Sharad S. Singhal, Sushma Yadav, Jyotsana Singhal, Rit Vatsyayan, Ewa Zajac, Rafal Luchowski, Jozef Borvak, Karol Gryczynski, Yogesh C. Awasthi Department of Molecular Biology & Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107 *Address correspondence to: Sanjay Awasthi, M.D., Email: [email protected] Submitted 19 June 2009 and accepted 25 November 2009.
منابع مشابه
A Central Role of RLIP76 in Regulation of Glycemic Control
OBJECTIVE Pathology associated with oxidative stress frequently results in insulin resistance. Glutathione (GSH) and GSH-linked metabolism is a primary defense against oxidative stress. Electrophilic lipid alkenals, such as 4-hydroxy-t-2-nonenal (4HNE), generated during oxidative stress are metabolized primarily to glutathione electrophile (GS-E) conjugates. Recent studies show that RLIP76 is t...
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